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In real-world tolerance tests, a repeat-insult patch test on an eye lotion with 0.2% Centella extract showed no irritation or allergic contact dermatitis in 54 subjects

Drop the per-dose amount by 50 to 100 mcg

This suggests the peptide's efficacy may be enhanced in subjects consuming higher-fat diets, though the effects on body composition remain significant across dietary conditions

Psychoneuroendocrinology 36 , 6876, (2011)